Université de Nantes - UFR Médecine - Publications du département de biologie cellulaire

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Publications du département de biologie cellulaire

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2010

F. Tabet, A.T. Remaley, A.I. Segaliny, J. Millet, L. Yan, S. Nakhla, P.J. Barter, K.A. Rye & G. Lambert (2010) The 5A apolipoprotein A-I mimetic peptide displays anti-inflammatory and antioxidant properties in vivo and in vitro. Arterioscler. Thromb. Vasc. Biol. 30, 246-252.

E. Nobecourt, F. Tabet, G. Lambert, R. Puranik, S. Bao, L. Yan, M.J. Davies, B.E. Brown, A.J. Jenkins,G.J. Dusting, D.J. Bonnet, L.K. Curtiss, P.J. Barter, K.A. Rye (2010) "Non-Enzymatic Glycation Impairs the Anti-Inflammatory Properties of Apolipoprotein A-I". Arterioscler. Thromb. Vasc. Biol. 30, 766-772.

D.C. Chan, S.J Hamilton, K.A. Rye, G.T. Chew, A.J. Jenkins, G. Lambert, G.F. Watts (2010) "Fenofibrate concomitantly decreases serum PCSK9 and VLDL particle concentrations in statin-treated type 2 diabetic patients". Diabetes Obes. Metab. 12, 752-756.

O.A. Akram, A. Bernier, F. Petrides, G. Wong, G. Lambert (2010) "Beyond LDL cholesterol, a new role for PCSK9". Arterioscler. Thromb. Vasc. Biol. 30, 1279-1281.

Forest V, Tirouvanziam A, Perigaud C, Fernandes S, Fusellier M, Desfontis J-C, Toquet C, Heymann M-F, Crochet D, Lemarchand P. Cell distribution after intracoronary bone marrow stem cell delivery in damaged and undamaged myocardium: implications for clinical trials. Stem Cell Research & Therapy 2010; 1 (1):4.

Kanashiro-Takeuchi RM, Tziomalos K, Takeuchi LM, Treuer AV, Lamirault G, Dulce R, Hurtado M, Song Y, Block NL, Rick F, Klukovits A, Hu Q, Varga JL, Schally AV, Hare JM. (2010) Cardioprotective effects of growth hormone-releasing hormone agonistafter myocardial infarction. Proc Natl Acad Sci U S A. 107(6):2604-9.

Heidecker B, Lamirault G, Kasper EK, Wittstein IS, Champion HC, Breton E, Russell SD, Hall J, Kittleson MM, Baughman KL, Hare JM. (2010) The gene expression profile of patients with new-onset heart failure reveals important gender-specific differences. Eur Heart J. 31(10):1188-96.

Lamirault G, Le Meur N, Roussel JC, Cunff MF, Baron D, Bihouée A, Guisle I, Raharijaona M, Ramstein G, Teusan R, Chevalier C, Gueffet JP, Trochu JN, Léger JJ, Houlgatte R, Steenman M. (2010) Molecular risk stratification in advanced heart failure patients. J Cell Mol Med. 14(6B):1443-52.

Rolli-Derkinderen M., Toumaniantz G., Pacaud P. and Loirand G. (2010) RhoA Phosphorylation Induces Rac1 Release from GDIα and Stimulation of Vascular Smooth Muscle Cell Migration. Mol Cell Biol. Aug 9. [Epub ahead of print].

Roncalli J, Mouquet F, Piot C, Trochu JN, Le Corvoisier P, Neuder Y, Le Tourneau T, Agostini D, Gaxotte V, Sportouch C, Galinier M, Crochet D, Teiger E, Richard MJ, Polge AS, Beregi JP, Manrique A, Carrie D, Susen S, Klein B, Parini A, Lamirault G, Croisille P, Rouard H, Bourin P, Nguyen JM, Delasalle B, VanzettoG, Van Belle E, Lemarchand P. (2010) Intracoronary autologous mononucleated bone marrow cell infusion for acute myocardial infarction: results of the randomized multicenter BONAMI trial. Eur Heart J. 2010 Dec 2. [Epub ahead of print].

2009

G. Lambert, F. Charlton, K.A. Rye & D.E. Piper (2009) Molecular Basis of PCSK9 Function Atherosclerosis 203,1-7.

S. Patel, R. Puranik, S. Nakla, P. Lundman, R. Stocker, X.S. Wang, G. Lambert, K.A. Rye, P.J. Barter, S.J. Nicholls & D.S. Celermajer (2009) Acute hypertriglyceridemia in humans increases the triglyceride content and decreases the anti-inflammatory capacity of HDL Atherosclerosis 204, 424-428.

K.A. Rye, C.A. Bursill, G. Lambert, F. Tabet & P.J. Barter (2009) The metabolism and antiatherogenic properties of HDL J. Lipid Res. Suppl: S195-S200.

D.C. Chan, G. Lambert, K.A. Rye, E.M.M. Ooi, P.H. B Barrett, G.F. Watts (2009)"Plasma PCSK9: a marker of LDL-apolipoprotein B-100 catabolism?" Clin. Chem. 55, 2049-2052.

Audigane, L., Kerfant, BG., El Harchi, A., Lorenzen-Schmidt, I., Toumaniantz, G., Cantereau, A., Potreau, D., Charpentier, F., Noireaud, J., Gauthier, C. (2009) Rabbit, a relevant model for the study of cardiac beta 3-adrenoceptors. Exp Physiol. 94(4):400-11.

Gaborit N, Wichter T, Varro A, Szuts V, Lamirault G, Eckardt L, Paul M, Breithardt G, Schulze-Bahr E, Escande D, Nattel S, Demolombe S. Transcriptional profiling of ion channel genes in Brugada syndrome and other right ventricular arrhythmogenic diseases. Eur Heart J. 2009 ;30(4):487-96.

Chopard A, Lecunff M, Danger R, Lamirault G, Bihouee A, Teusan R, Jasmin BJ, Marini JF, Leger JJ. Large-scale mRNA analysis of female skeletal muscles during 60 days of bed rest with and without exercise or dietary protein supplementation as countermeasures. Physiol Genomics. 2009;38(3):291-302.

Beigi F, Oskouei BN, Zheng M, Cooke CA, Lamirault G, Hare JM. Cardiac nitric oxide synthase-1 localization within the cardiomyocyte is accompanied by the adaptor protein, CAPON. Nitric Oxide. 2009 Nov-Dec;21(3-4):226-33
Leblond A-L, Naud P, Forest V, Gourden C, Sagan C, Romefort B, Mathieu E, Delorme B, Collin C, Pagès J-C, Sensebé L, Pitard B, Lemarchand P. Developing cell therapy techniques for respiratory disease: Intratracheal delivery of genetically engineered stem cells in a murine model of airway injury. Human Gene Therapy 2009 :20(11);1329-1343.

Toumaniantz, G., Ferland-McCollough, D., Cario-Toumaniantz, C., Pacaud, P., Loirand, G. (2009) The Rho protein exchange factor Vav3 regulates vascular smooth muscle cell proliferation and migration. Cardiovasc Res. 86(1):131-40.

Fernandes S, van Rijen HVM, Forest V, Evain S, Leblond A-L, Mérot J, Charpentier F, de Bakker JMT, Lemarchand P. Cardiac cell therapy: overexpression of connexin43 in skeletal myoblasts and prevention of ventricular arrhythmias. J Cell Mol Med 2009; 13(9B):3703-3712.

Guilluy, C., Brégeon, J., Toumaniantz, G., Rolli-Derkinderen, M., Retailleau, K., Loufrani, L., Henrion, D., Torres, R., Offermanns, S., Pacaud, P., Loirand, G. (2009) The Rho exchange factor Arhgef1 is essential for Angiotensin II-dependent regulation of vascular tone and hypertension. Nature Med 16(2):183-90.

2008

V.M. Homer, A.D. Marais, F. Charlton, A.D. Laurie, N. Hurndell, R. Scott, F. Mangili, D.R. Sullivan, P.J. Barter, K.A. Rye, P.M. George & G. Lambert (2008) Identification and Characterization of two non-secreted PCSK9 mutants associated with Familial Hypercholesterolemia in cohorts from New Zealand and South Africa Atherosclerosis 196, 659-666.

S.H. Ahn, Y.M. Shah, J. Inoue, K. Morimura, I. Kim, S.H. Yim, G. Lambert, R. Kurotani, F.J. Gonzalez & Y. Inoue (2008) Hepatocyte nuclear factor 4a in the intestinal epithelial cells protects against inflammatory bowel disease Inflamm. Bowel Dis. 14, 908-920.

G. Lambert, N. Ancellin, F. Charlton, D. Comas, J. Pilot, A. Keech, S. Patel, D.R. Sullivan, J.S. Cohn, K.A. Rye & P.J. Barter (2008) Plasma PCSK9 concentrations correlate with LDL and total cholesterol in diabetic patients and are decreased by fenofibrate treatment Clin. Chem. 54, 1038-1045.

G. Lambert, F. Charlton, K.A. Rye & D.E. Piper (2008) Molecular Basis of PCSK9 Function Atherosclerosis (sous presse)

Roussel JC, Baron O, Périgaud C, Bizouarn P, Pattier S, Habash O, Mugniot A, Petit T, Michaud JL, Heymann MF, Treilhaud M, Trochu JN, Gueffet JP, Lamirault G, Duveau D, Despins P. Outcome of heart transplants 15 to 20 years ago: graft survival, post-transplant morbidity, and risk factors for mortality. J Heart Lung Transplant. 2008 ;27(5):486-93.

2007

G. Lambert (2007) Unravelling the functional significance of PCSK9 Curr. Opin. Lipidol. 18, 304-309.

Bossard F, Robay A, Toumaniantz G, Dahimene S, Becq F, Merot J, Gauthier C. NHE-RF1 protein rescues DeltaF508-CFTR function. Am J Physiol Lung Cell Mol Physiol. 2007 ;292(5):L1085-94.

2006

M. Chetiveaux, F. Lalanne, G. Lambert, Y. Zaïr, K. Ouguerram & M. Krempf (2006) Kinetics of preb1 HDL and aHDL in type II diabetic patients. Eur. J. Clin. Invest. 36, 29-34.

P. Costet, B. Cariou, G. Lambert, F. Lalanne, B. Lardeux, A.L. Jarnoux, A. Grefhorst, B. Staels & M. Krempf (2006). Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory-element binding protein 1c. J. Biol. Chem. 281, 6211-6218.

G. Lambert, M. Krempf & P. Costet (2006). PCSK9: a promosing therapeutic target for dyslipidemias?. Trends Endocrinol. Metab. 17, 79-81.

S.H. Yim, Y. Shah, S. Tomita, H.D. Morris, O. Gravilova, G. Lambert, J.M. Ward & F.J. Gonzalez (2006). Endothelial Cell specific disruption of the aryl hydrocarbon receptor nuclear transporter (Arnt) gene causes hepatic vascular defects and partial embryologic lethality. Hepatology 44, 550-560.

G. Lambert, A.L. Jarnoux, T. Pineau, O Pape, M Chetiveaux, C. Laboisse, M. Krempf & P. Costet (2006). Fasting Induces Hyperlipidemia in Mice Overexpressing PCSK9: Lack of Modulation of VLDL Hepatic Output by the LDLr. Endocrinology, 147, 4885-4895.

E.A. Hanniman, G. Lambert, Y. Inoue, F.J. Gonzalez & C.J. Sinal (2006). Apolipoprotein A-IV is regulated by nutritional and metabolic stress: involvement of glucocorticoids, HNF-4a and PGC-1a. J. Lipid Res. 47, 2503-2514.

Fernandes S, Amirault J-C, Lande G, Nguyen J-M, Forest V, Bignolais O, Lamirault G, Heudes D, Orsonneau J-L, Heymann M-F, Charpentier F, Lemarchand P. Autologous myoblast transplantation after myocardial infarction increases the inducibility of ventricular arrhythmias. Cardiovascular Research 2006 ;69 :348-358.

Troadec MB, Glaise D, Lamirault G, Le Cunff M, Guérin E, Le Meur N, Détivaud L, Zindy P, Leroyer P, Guisle I, Duval H, Gripon P, Théret N, Boudjema K, Guguen-Guillouzo C, Brissot P, Léger JJ, Loréal O. Hepatocyte iron loading capacity is associated with differentiation and repression of motility in the HepaRG cell line. Genomics. 2006 ;87(1):93-103.

Lamirault G, Gaborit N, Le Meur N, Chevalier C, Lande G, Demolombe S, Escande D, Nattel S, Léger JJ, Steenman M. Gene expression profile associated with chronic atrial fibrillation and underlying valvular heart disease in man. J Mol Cell Cardiol. 2006 ;40(1):173-84

2005

F. Lalanne, G. Lambert*, M.J.A. Amar, M. Chetiveaux, Y. Zaïr, A.L. Jarnoux, K. Ouguerram, J. Friburg, N.G. Seidah, H.B. Brewer Jr., M. Krempf & P. Costet (2005) Wild-type PCSK9 inhibits LDL clearance but does not affect apoB containing lipoprotein production in mouse and cultured cells J. Lipid Res. 46, 1312-1319.

E.A. Hanniman, G. Lambert, T.C. McCarthy & C.J. Sinal (2005) Loss of functional farnesoid X-receptor increases atherosclerotic lesions in apolipoprotein E-deficient mice J. Lipid Res. 46, 2595-2604.

Rozec B, Serpillon S, Toumaniantz G, Sèze C, Rautureau Y, Baron O, Noireaud J, Gauthier C. Characterization of beta3-adrenoceptors in human internal mammary artery and putative involvement in coronary artery bypass management. J Am Coll Cardiol. 2005 Jul 19;46(2):351-9.

Robay A, Toumaniantz G, Leblais V, Gauthier C. Transfected beta3- but not beta2-adrenergic receptors regulate cystic fibrosis transmembrane conductance regulator activity via a new pathway involving the mitogen-activated protein kinases extracellular signal-regulated kinases. Mol Pharmacol. 2005 ;67(3):648-54.

Royer A, Demolombe S, El Harchi A, Le Quang K, Piron J, Toumaniantz G, Mazurais D, Bellocq C, Lande G, Terrenoire C, Motoike HK, Chevallier JC, Loussouarn G, Clancy CE, Escande D, Charpentier F. Expression of human ERG. K+ channels in the mouse heart exerts anti-arrhythmic activity. Cardiovasc Res. 2005 Jan 1;65(1):128-37.

Durand E, Al Haj Zen A, Addad F, Brasselet C, Caligiuri G, Vinchon F, Lemarchand P, Desnos M, Bruneval P, Lafont A. Adenovirus-mediated gene transfer of superoxide dismutase and catalase decreases restenosis after balloon angioplasty. J Vasc Res. 2005 ;42(3):255-65.

Steenman M, Lamirault G, Le Meur N, Léger JJ. Gene expression profiling in human cardiovascular disease. Clin Chem Lab Med. 2005;43(7):696-701.

Gaborit N, Steenman M, Lamirault G, Le Meur N, Le Bouter S, Lande G, Léger J, Charpentier F, Christ T, Dobrev D, Escande D, Nattel S, Demolombe S. Human atrial ion channel and transporter subunit gene-expression remodeling associated with valvular heart disease and atrial fibrillation. Circulation. 2005;112(4):471-81.

Steenman M, Lamirault G, Le Meur N, Le Cunff M, Escande D, Léger JJ. Distinct molecular portraits of human failing hearts identified by dedicated cDNA microarrays. Eur J Heart Fail. 2005 Mar 2;7(2):157-65.

2004

T.E. Akiyama, G. Lambert*, C.J. Nicol*, K. Matsusue, J.M. Peters, H.B. Brewer Jr. & F.J. Gonzalez (2004) Peroxisome proliferator-activated receptor b/d regulates very low density lipoprotein production and catabolism in mice on a western diet J. Biol. Chem. 279, 20874-20881.

Y. Inoue, J. Inoue, G. Lambert, S.E. Him & F.J. Gonzalez (2004) Disruption of hepatic C/EBPa results in impaired glucose tolerance and age-dependent hepatosteatosis J. Biol. Chem. 279, 44640-44748.

G. Lambert, P. Costet, M. Krempf & F. Lalanne (2004) PCSK9 : a new gene involved in familial hypercholesterolemia Med. Sci. 20, 1068-1070.

K. Matsusue , O. Gavrilova, G. Lambert, H.B. Brewer Jr., J.M. Ward, Y. Inoue, D. LeRoith & F.J. Gonzalez (2004) Hepatic C/EBPa mediates induction of lipogenesis and regulation of glucose homeostasis in leptin-deficient mice Mol. Endocrinol. 18, 2751-2764.

G. Lambert, M. Chetiveaux, G. Sénard, D. Drui & M. Krempf (2004) Intestinal cholesterol absorption and NPC1-L1 Med. Sci. 20, 636-638.

Mallem MY, Toumaniantz G, Serpillon S, Gautier F, Gogny M, Desfontis JC, Gauthier C. Impairment of the low-affinity state beta1-adrenoceptor-induced relaxation in spontaneously hypertensive rats. Br J Pharmacol. 2004 ;143(5):599-605.

Le Meur N, Lamirault G, Bihouée A, Steenman M, Bédrine-Ferran H, Teusan R, Ramstein G, Léger JJ. A dynamic, web-accessible resource to process raw microarray scan data into consolidated gene expression values: importance of replication. Nucleic Acids Res. 2004 ;32(18):5349-58.

2003

G. Lambert, M.J.A. Amar, G. Guo, H.B. Brewer Jr., F.J. Gonzalez & C.J. Sinal (2003) The Farnesoid X-receptor is an essential regulator of cholesterol homeostasis J. Biol. Chem. 278, 2563-2570.

K. Matsusue , M. Haluzik, G. Lambert, S-H Yim, O. Gavrilova, J.M. Ward, B. Brewer Jr., M.L. Reitman & F.J. Gonzalez (2003) Liver specific disruption or PPARg in leptin deficient mice improves fatty liver but aggravates diabetic phenotypes J. Clin. Invest. 111, 737-747.

G. Guo, G. Lambert, M. Negishi, J.M. Ward, H.B. Brewer, Jr., S.A. Kliewer, F.J. Gonzalez & C.J. Sinal (2003) Complementary Roles of Farnesoid X Receptor, Pregnane X Receptor, and Constitutive Androstane Receptor in Protection against Bile Acid Toxicity J. Biol. Chem. 278, 45062-45071.

Le Bouter S, Demolombe S, Chambellan A, Bellocq C, Aimond F, Toumaniantz G, Lande G, Siavoshian S, Baró I, Pond AL, Nerbonne JM, Léger JJ, Escande D, Charpentier F. Microarray analysis reveals complex remodeling of cardiac ion channel expression with altered thyroid status: relation to cellular and integrated electrophysiology. Circ Res. 2003 ;92(2):234-42.

Tavernier G, Toumaniantz G, Erfanian M, Heymann MF, Laurent K, Langin D, Gauthier C. Beta3-Adrenergic stimulation produces a decrease of cardiac contractility ex vivo in mice overexpressing the human beta3-adrenergic receptor. Cardiovasc Res. 2003 ;59(2):288-96.

Bottino R, Lemarchand P, Trucco M, Giannoukakis N. Gene- and cell-based therapies for type I diabetes mellitus (review). Gene Therapy 2003;10(10):875-89.

Tralhão JG, Schaefer L, Micegova M, Evaristo C, Schönherr E, Kayal S, Veiga-Fernandes H, Danel C, Iozzo RV, Kresse H, Lemarchand P. In vivo selective and distant killing of cancer cells using adenovirus-mediated decorin gene transfer. FASEB J 2003; 17(3):464-6.

Al Haj Zen A, Lafont A, Durand E, Brasselet C, Lemarchand P, Godeau G, Gogly B. Effect of adenovirus-mediated overexpression of decorin on metalloproteinases, tissue inhibitors of metalloproteinases and cytokines secretion by human gingival fibroblasts. Matrix Biol. 2003; 22(3):251-8.

Steenman M, Chen YW, Le Cunff M, Lamirault G, Varró A, Hoffman E, Léger JJ. Transcriptomal analysis of failing and nonfailing human hearts. Physiol Genomics. 2003 ;12(2):97-112.

2002

C.W. Joyce, M.J.A. Amar, G. Lambert, B.L. Vaisman, B. Paigen, J. Fruchart-Najib, R.F. Hoyt, E.B. Neufeld, A.T. Remaley, D.S. Fredrickson, H.B. Brewer, Jr. & S. Santamarina-Fojo (2002) The ATP binding cassette transporter 1 (ABCA1) modulates the development of aortic atherosclerosis in C57Bl/6 and apoE-knockout mice Proc. Natl. Acad. Sci. USA 99, 407-412.

T.E. Akiyama, S. Sakai, G. Lambert, C.J. Nicol, K. Matsusue, S. Pimprale, Y.H. Lee, M. Ricote, C. Glass, H.B. Brewer Jr. & F.J. Gonzalez (2002) Conditional disruption of the PPARg gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux Mol. Cell. Biol. 22, 2607-2619.

M. Chetiveaux , H. Nazih, V. Ferchaud-Roucher, G. Lambert, Y. Zair, M. Masson, K. Ouguerram, D. Bouhours & M Krempf (2002) The differential apoA-I enrichment of pre-b1 and a-HDL is detectable by gel filtration separation J. Lipid Res. 43, 1986-1993.

Rautureau Y, Toumaniantz G, Serpillon S, Jourdon P, Trochu JN, Gauthier C. Beta 3-adrenoceptor in rat aorta: molecular and biochemical characterization and signalling pathway. Br J Pharmacol. 2002 ;137(2):153-61.

Bertry-Coussot L, Lucas B, Danel C, Halbwachs-Mecarelli L, Bach J-F, Chatenoud L, Lemarchand P. Long term reversal of established autoimmunity upon transient blockade of the LFA-1/ICAM-1 pathway. J. Immunology 2002; 168: 3641-3648.

Barrou B, Bertry-Coussot L, Morin S, Sainz J, Lucas B, Bitker MO, Debré P, Lemarchand P. Prolonged islet allograft survival by adenovirus-mediated transfer of sICAM-1/Ig immunoadhesin gene. Human Gene Therapy 2002; 13: 1441-1450.

Witko-Sarsat V, Canteloup S, Durant S, Desdouets C, Chabernaud R, Lemarchand P, Descamps-Latscha B. Cleavage of P21/waf1 by proteinase 3, a myeloid specific serine protease, potentiates cell proliferation. J. Biol. Chem. 2002; 277(49):47338-47.

Mis à jour le 27 janvier 2011 par Florence QUILLIOT